Through research done on causes of late-onset Alzheimer’s disease (AD), a link has been made between the amyloid-beta protein and the APOE ε4 allele. Not only do they play a major role in leading to AD, they also result in an increased risk of brain injury. Looking at studies done on patients with traumatic brain injuries, with an emphasis on injuries received while boxing, the possibility exists that having the APOE ε4 allele can lead to being more at risk for having a traumatic brain injury than non-carriers. Currently, there is no screening for the APOE ε4 allele in prospective athletes. The topic of potential screening should be further discussed as well as additional research done to be better equipped for educating the public on possible risks.