Surgeons can compare three pre-graft methods for treating burn wounds. When using the split-thickness skin graft procedure, many different wound bed covers can be used. The lack of available donor sites can delay skin grafting. During this time, priming the wound bed is the best chance a patient has for full healing. An excised wound bed, an artificial dermal template, and a granulation tissue induced by cellulose sponge are all methods to prepare the wound for a split-thickness skin graft. All three wound bed covers are easy to apply and can be placed on bones and deep wounds, often without pain. Achieving reduced scar formation begins with a well-primed wound bed that can significantly improve the outcome of skin replacement.